Molecular chaperones and neuronal proteostasis
نویسندگان
چکیده
منابع مشابه
Extracellular chaperones and proteostasis.
There exists a family of currently untreatable, serious human diseases that arise from the inappropriate misfolding and aggregation of extracellular proteins. At present our understanding of mechanisms that operate to maintain proteostasis in extracellular body fluids is limited, but it has significantly advanced with the discovery of a small but growing family of constitutively secreted extrac...
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*Correspondence to: Richard I. Morimoto; Email: [email protected] Submitted: 05/30/2013; Accepted: 06/03/2013 http://dx.doi.org/10.4161/cc.25703 Comment on: Kirstein-Miles J, et al. EMBO J 2013; 32:1451-68; PMID:23604074; http://dx.doi.org/10.1038/emboj.2013.87 The production of newly synthesized proteins is a key process of protein homeostasis that initiates the biosynthetic flux of ...
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Cellular differentiation, developmental processes, and environmental factors challenge the integrity of the proteome in every eukaryotic cell. The maintenance of protein homeostasis, or proteostasis, involves folding and degradation of damaged proteins, and is essential for cellular function, organismal growth, and viability . Misfolded proteins that cannot be refolded by chaperone machineries ...
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ژورنال
عنوان ژورنال: Seminars in Cell & Developmental Biology
سال: 2015
ISSN: 1084-9521
DOI: 10.1016/j.semcdb.2015.03.003